Gastroretentive mucoadhesive tablet of lafutidine for controlled release and enhanced bioavailability
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چکیده
منابع مشابه
Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl
To prolong the residence time of dosage forms within the gastrointestinal tract until all drug is released at the desired rate is one of the real challenges for oral controlled-release drug delivery systems. This study was designed to develop a controlled-release floating matrix tablet and floating raft system of Mebeverine HCl (MbH) and evaluate different excipients for their floating behavior...
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The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...
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Objective: The objective of the present work was to formulate a gastroretentive dosage form of Valacyclovir, an anti viral drug. Methods: Valacyclovir gastroretentive mucoadhesive tablets were prepared using polymers such as Carbopol 974P and hydroxy propyl methyl cellulose (HPMC) K4M, in different proportions by wet granulation technique. Compatibility studies were performed by FTIR spectrosco...
متن کاملDevelopment of Osmotically Controlled Mucoadhesive Cup-Core (OCMC) Tablet for The Anti-Inflammatory Activity
The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...
متن کاملDesign and Development of Mucoadhesive Acyclovir Tablet
The purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. A 32 full factorial design was employed to study the effect of independent variables like Carbopol-934P and hydroxypropyl methylcellulose K100M, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2014
ISSN: 1071-7544,1521-0464
DOI: 10.3109/10717544.2013.877099